Diagnostics

In addition to typical laboratory analysis, we utilize advanced diagnostic testing to identify the root causes of conditions.  This typically includes GI screening and chronic infections (if necessary), Cardio-metabolic profiling, Complete hormone evaluation, and advanced nutritional assessments.  In addition, we can evaluate for food sensitivities and intolerances as well as a variety of less common conditions.   We feature testing from Genova Diagnostics, Precision Analytics, Cyrex Laboratories, Boston Heart, Doctor’s Data and several others.

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Hormone Replacement

Diet and Nutrition

There is a world of difference between synthetic hormone replacement and bioidentical hormone replacement (BHRT). BHRT is the term used for bioidentical hormones. They are structurally identical to hormones that are produced by the human body. They are usually compounded in a compounding pharmacy and derived from plants. Bioidentical Hormone Replacement (BHRT) offers a more effective replacement (you feel better) without the risks associated with standard hormone replacement therapy (HRT).
o    Thyroid
o    Adrenal
o    Progesterone
o    Estrogens
o    Testosterone
o    DHEA
o    See also Peptide Therapy

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Peptide Therapy

A peptide is a short chain of amino acids that are linked together, and can be thought of as a small protein. To date, over 7,000 naturally-occurring peptides have been identified. In our bodies, these small proteins typically act as signaling molecules. They bind to receptors on the cell surface and tell other cells and molecules what to do. 

Peptide therapy, or the use of specific peptides in treatment, has gained great popularity in recent years. This is due largely to the fact that these peptides are highly specific (i.e., only do what you want them to do) while also being well-tolerated and safe. As of January 2015, there were over 60 US FDA-approved peptide medications, 140 peptide drugs being evaluated in clinical trials, and 500 in pre-clinical development. 

Most of these peptide drugs are administered intradermally, but can also come in the form of transdermal creams, nasal sprays, and oral tablets. 

•    Thymosin alpha-1 (T α 1) is a peptide, or small protein, consisting of 28 amino acids. T α 1 is produced naturally by the thymus gland. The thymus is located behind the sternum and between the lungs, and is where immune cells known as T cells mature and are released, prompted to do so by the T α 1 peptide. T cell production and action within the body is vital to adaptive immunity—the mode by which immune cells are able to recognize and eradicate foreign invaders. 
T α 1 has been found to have a profound effect on the immune system specifically, T α 1 has been shown to enhance the function of certain immune cells called T and dendritic cells. This is very important to anyone with a depressed immune system or suffering from an infection

•    Thymosin beta 4 (Tβ4) is the predominant form of thymosin in our bodies. It has been found in high concentrations in wound tissue and certain blood cells involved in clotting, signifying its important role in the healing process. In fact, recent studies have revealed that the first gene to be upregulated after an injury is the Tβ4 gene. As the body begins the recovery process, Tβ4 aids in the creation of new vessels in the injured area, which carry blood, nutrients, and reparative substances to the site. Tβ4 also has anti-inflammatory properties, and works to decrease the amount of inflammatory substances, called cytokines. Inflammation plays a large role in many of the symptoms associated with a large number of conditions (i.e., Lyme disease, CFS, FM, autoimmune diseases, infections, etc.), making the potential impact of Tβ4 quite extensive. 

The role of Tβ4 in the process of immune regulation has lead to its use as a valuable therapeutic agent. Tβ4 has been used in the treatment of HIV, AIDS, Influenza, colds, and various infections. It has been utilized in the management of various inflammatory conditions, as well as part of treatment following heart attack due to its cardio and neuroprotective effects. 

•    Growth Hormone Secretagogues (GHSs)
This class of peptides includes several therapeutics that stimulate growth hormone (hGH) secretion. Each peptide varies slightly as far as structure and mechanism of action. Thus, a certain peptide may be preferred depending on the patient’s health status and desired outcome. 

- Ipamorelin is utilized in order to stimulate the pituitary gland. It stands out among other GHSs due to its enhanced specificity. Ipamorelin is one of the cleanest, most versatile and safest GHRP’s. This peptide generates similar increases in growth hormone secretion, but without the appetite stimulation and increase in cortisol, acetylcholine, prolactin, and aldosterone seen with other peptides in its class. This peptide has been found to be very well-tolerated. Benefits include improved sleep, mood and muscle density.

- CJC 1295 This particular peptide offers therapeutic benefits similar to those of hGH. CJC 1295 is a growth hormone releasing hormone (GHRH) analogue. In other words, it is a molecule that serves the same purpose as does GHRH—the hormone that stimulates the anterior pituitary to release hGH. However, unlike GHRH, which has a half-life of only minutes after IV administration, CJC 1295 is able to remain active in the body for extended periods due to its ability to bind to a protein in the blood known as albumin and avoid degradation by various enzymes. CJC 1295 increases an important growth factor, IGF-1, in addition to hGH, leading to fat loss, lean muscle growth, and enhanced sleep. 
    
•    AOD 9064. This peptide is a modified fragment of hGH which contains the portion of the molecule that is believed to be responsible for hGH’s anti-obesity effects. The peptide has been shown to increase fat burning without the increase in blood sugar and growth rate that has been seen with hGH itself. AOD 9604 has been deemed safe for chronic use by the FDA, receiving Human GRAS status in 2014. In addition to its utility as an anti-obesity peptide, AOD 9604 has been shown to have very favorable cartilage repair and regenerative properties, especially when paired with peptide BPC 157. 
    
•    SARMs are selective androgen receptor modulators. Androgens are naturally occurring hormones - such as testosteron - that regulate the development and maintenance of male sex characteristics. SARMs provide the benefits of anabolic steroids (i.e., increased muscle mass/strength, fat loss, increased bone density, increased libido) without the quantity and/or severity of unwanted effects. SARMs are not toxic to the liver, separating them from most oral steroids and making them an attractive treatment option to those looking to benefit from anabolic steroid drugs.
    
•    MGF stands for mechano growth factor - a peptide derived from insulin-like growth factor-1 (IGF-1), which plays a large role in childhood development and continues to have anabolic effects throughout adulthood. MGF has the ability to encourage repair and growth of wasted tissue through the activation of muscle stem cells, thereby increasing the synthesis of proteins necessary for tissue growth. This peptide is ideal of anyone suffering from muscle loss, either due to old age or a particular condition (i.e., HIV, cancer, etc.)
    
•    Cerebrolysin - also known as FPE 1070 - is a synthetic nootropic drug. Nootropic drugs are substances that enhance cognitive functions such as memory, creativity, and motivation in otherwise healthy individuals. This peptide is extremely small, allowing it to penetrate the blood-brain barrier and act directly on the neurons of the central nervous system. Cerebrolysin has been found to improve the metabolic activity of brain tissue, shield neurons from harmful substances, and stimulate the peripheral and central nervous systems. In addition to its utility as a nootropic substance, the drug has potential as part of a treatment plan addressing Alzheimer’s disease, stroke, and moderate to severe head injury.
    
•    Bremelanotide PT 141 was developed from Melanotan II, targeting its aphrodisiac effects. This peptide has been shown to have a substantial effect on libido, generating sexual arousal in both men and women within minutes of administration. It has been shown to be effective in treating erectile dysfunction, even in men who have not responded to other ED treatments, such as Viagara. This peptide is also able to cross the blood-brain-barrier, bypassing the vascular system and acting at the level of the central nervous system. This property gives Bremelanotide an advantage over traditional ED drugs, which can decrease blood pressure to dangerous levels. This peptide can be administered as a nasal spray, making its use convenient and discreet.
    
•    Melanotan II is an analogue of alpha melanocyte stimulating hormone, the hormone responsible for pigmentation in skin and hair. This peptide has been shown not only to increase skin pigmentation, resulting in a substantially tanner skin tone, but also to stimulate fat loss and increase libido. Its aphrodisiac effects were so substantial that it was the basis for the development of another peptide designed exclusively to address erectile and sexual dysfunction—Bremelanotide PT 141.
LDN (Low Dose Naltrexone)

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LDN (Low-dose naltrexone)

LDN is a novel treatment for a variety of conditions.  Naltrexone itself was approved by the FDA in 1984 in a 50mg dose for the purpose of helping heroin or opium addicts, by blocking the effect of such drugs. By blocking opioid receptors, naltrexone also blocks the reception of the opioid hormones that our brain and adrenal glands produce: beta-endorphin and metenkephalin. Many body tissues have receptors for these endorphins and enkephalins, including virtually every cell of the body's immune system. 

The brief blockade of opioid receptors between 2 a.m. and 4 a.m. that is caused by taking LDN at bedtime each night is believed to produce a prolonged up-regulation of vital elements of the immune system by causing an increase in endorphin and enkephalin production. Normal volunteers who have taken LDN in this fashion have been found to have much higher levels of beta-endorphins circulating in their blood in the following days. In general, in people with diseases that are partially or largely triggered by a deficiency of endorphins (including cancer and autoimmune diseases), or are accelerated by a deficiency of endorphins (such as HIV/AIDS), restoration of the body's normal production of endorphins is the major therapeutic action of LDN. 
•    For more information visit: http://www.lowdosenaltrexone.org/

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Diet and Nutrition

Functional Nutrition includes individualized dietary and nutritional protocols and herbal formulas. Functional nutritional medicine is anchored by an examination of the core clinical imbalances that underlie various disease conditions. Those imbalances arise as environmental inputs such as diet; nutrients (including air and water), exercise, and trauma are processed by one’s body, mind, and spirit through a unique set of genetic predispositions, attitudes, and beliefs. The fundamental physiological processes include communication, both outside and inside the cell; bioenergetics, or the transformation of food into energy; replication, repair, and maintenance of structural integrity, from the cellular to the whole body level; elimination of waste; protection and defense; and transport and circulation.

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Weight Loss

Our program employs a modified ketogenic diet and staged HCG protocol in conjunction with specific nutrient injections, supplements and supportive peptides. Human Chorionic Gonadotropin (HCG), has been safely used to enhance and accelerate weight loss for over 60 years. HCG is a naturally occurring hormone produced in large quantities during the early stages pregnancy. This hormone allows the body to mobilize fat and use it as energy for both mother and baby. For weight loss, research suggests a significantly less dose or injection (approximately 125 IU to 200 IU) results in a weight loss of a pound per day, and often more, when accompanied by a very low calorie diet of approximately 500 calories. In a famine state, the very low calorie intake is what activates the HCG hormones to seek those stubborn fat stores that you want to get rid of.

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Herbal Medicine

Western Botanical Medicine (also called phytotherapy): the use of plants or plant extracts for medicinal purposes. It is developed primarily out of the Egyptian and later Greek systems of medicine. Currently botanical medicine is considered a science that includes pharmacognosy (the study of plant constituents), pharmacodynamics (the effect of the herb/drug on the body), and pharmacokinetics (the study of the body on the herb/drug).

Oriental Herbs are a combination of natural plant, animal, and mineral substances used to heal and balance the human body mind and emotions. Herbs can help balance the organ’s yin and yang (Opposing biological actions) and invigorate the Qi (Life Force) and blood.

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